Matou te tuʻuina atu le 5- Azacytidine API

Matou te mitamita e ofo atu 5- Azacytidine API, o se vailaʻau maualuga maualuga o loʻo faʻaaogaina e avea o se antineoplastic ma antiviral agent. O lenei API o loʻo faʻaaogaina muamua i togafitiga o le maʻi leukemia myeloid, myelodysplastic pattern, ma le masani myelomonocytic leukemia. O a tatou oloa o lo'o gaosia e tusa ai ma tu'utu'uga lelei, fa'aisa lona mama ma lelei. O lo'o avanoa i lapopo'a felanulanua'i e fetaui ma ou tulaga fa'apitoa. Faʻalagolago ia i matou e tuʻuina atu ia te oe se malosi faʻalagolago ma aoga o le 5- Azacytidine. fa'afeso'ota'i i matou i se taimi e a'oa'o atili ai e uiga i lenei oloa ma pe fa'apefea ona matou fesoasoani atu ia te oe.

O le a le Azacytidine?

5- Azacytidine paʻu, e lauiloa foi o le Azacitidine poʻo le 5-AC, o se vailaʻau vailaʻau. O le nucleoside analog e faia i le adenine base ma se mama-peipepa patch filifilia se nitrogen heterocycle e aofia ai le nitrogen. O se DNA methyltransferase aseta ma o loʻo faʻaaogaina i taimi uma e togafitia ai le myelodysplastic pattern (MDS), o se tulaga o le toto. O lona igoa vailaʻau o le 4- Amino- 1- (- D-ribofuranosyl) ( 1H) - tasi, ma lona numera CAS o le 320-67-2. O lona fua fa'ama'i ole C8H12N4O5, ma lona mamafa mole e 244.2 g/ spook. E mafai ona suia le faʻaaliga o kenera ma maua ai faʻamanuiaga faʻaleleia i tulaga e pei o le myelodysplastic pattern (MDS) e ala i le faʻaogaina o le DNA methylation process. E ala i le taofiofia o suiga ole DNA methylation, e faʻaleleia ai le tuputupu aʻe o sela hematopoietic maloloina ma faʻaliliuina le faʻaogaina o sela hematopoietic le atoatoa.

O le mauaina o le 5-Azacytidine's mauaina na amata mai i le 1950s. O se aotelega o ana sailiga e mafai ona maua iinei:

O le uluai Azacytidine API fa'atasiga na fa'atinoina i le 1958 e tagata su'esu'e mai le Vaega o Atina'e Vailaau Fa'atekonolosi a National Institutes of Health i le Iunaite Setete. Na latou faʻatūina o lenei mea e taofia ai le methylation o le DNA feaveaʻi.

O le National Cancer Institute(NCI) i le Iunaite Setete na amata faia suʻesuʻega fou ile azacytidine i 1964.

Azacitidine paʻu pasi su'esu'ega fou ma atina'e i tausaga ua mavae. O le US Food and Drug Administration (FDA) na tuʻuina atu le faʻamanuiaga o le Azacytidine (faʻatau atu e pei o Vidaza) i le 1985 mo le faʻaogaina o le myelodysplastic pattern (MDS). O se taunuuga, ua faʻaaogaina i taimi uma e togafitia ai foi le MDS.

Faamatalaga autu

Igoa o oloa: 5-Azacytidine
CAS:320-67-2
MF:C8H12N4O5
MW: 244.2
EINECS: 206-280-2
MDL Nu.:MFCD00006539
Mama:99%
Mauaina: Mausali mo le 2 tausaga
solubility: Solu i le DMSO (e o'o atu i le 25 mg/ml), po'o le Vai (e o'o atu i le 12 mg/ml).
Fa'aoga: Va'aiga vaila'au po'o fa'aoga mo su'esu'ega.
afifiina: E tusa ai ma lau talosaga
Teuina: Tempera o le potu.
Fuafuaga fausaga:

Liu liusuavai: 226 i le 232 ℃

Mea fa'apuna: 534.5 ℃

Suavai soluble: soluble

Malosi: 2.08 g/cm ³

Itu ole moli: 277 ℃

Tulaga o le tulaga lelei

afifiina: 500g/pe;1kg/pe

Tulaga teuina: -20 ℃, susu-faʻamaonia, faʻamaufaʻailoga, ma moli faʻamaoniga

Tulaga felauaiga: 2-8 ℃ felauaiga

Vaega: Oona

Fa'avasegaga oona: sili ona o'ona

O'ona mata'utia: Tu'u gutu LD50 i isumu: 572 mg/kg; Iole o le manava LD50: 68 mg/kg

Uiga o lamatiaga mu: mu; O le mu e maua ai le asu oona oona oona oxide; Itu a'afiaga o vaila'au mo gasegase: faufau, pua'i, manava manava, ma fa'aitiitia sela pa'epa'e

Sui fa'amago: pa'u mago, foam, oneone, carbon dioxide, vai atomi

O le a le talosaga o le 5-Azacytidine paʻu ?

O fa'aoga autu ia mo 5-Azacytidine paʻu ma ona vaega fa'aoga:

1. Antimetabolic vailaʻau

Ole fa'ailoga autu ole leukemia myeloid acute lea e le aoga ile togafitiga masani. E faʻaaogaina foi mo le kanesa o le susu, melanoma, kanesa o le intestinal, ma isi. O faʻaaliga autu o le oona o le leukopenia, thrombocytopenia, ma le anemia. O le nausea ma le pua'i o ni fa'alavelave masani ia, e mafai ona fa'aleleia e ala i le fa'a'umi'umi o fa'afuga po'o le fa'aaogaina o vaila'au fa'ama'i 24 i le 48 itula a'o le'i togafitia. O isi a'afiaga oona e aofia ai le manava manava, fa'aletonu o le neuromuscular, fiva, toto maualuga, ma le mageso. O le faʻatulagaga e fou saunia 3-4 itula aʻo leʻi faʻaaogaina.

2.O le malosi o le faʻalavelave tuputupu aʻe ma le cytotoxic agent

Faʻasaina o le DNChemicalbookA methyltransferase, o se faiga faʻatonutonu taua mo le faʻaalia o kenera, faʻagaoioia, ma le faʻamalo; O mea e taofia ai le kanesa e vaivai le antibody (Gram positive); Faʻaaogaina e suʻesuʻe ai le aʻafiaga o DNA faʻafefiloi molelaʻau i le taimi o le DNA methylation process

3. O se mea e mafai ona taofia le tuputupu ae ma le cytotoxic carrier

Taofi le DNA methyltransferase, o se faiga fa'atulafonoina taua mo le fa'aaliga o le kenera, fa'againa o le kenera, ma le tapunia o le kene. O lenei mea e mafua ai le DNA demethylation poʻo le semi demethylation, faʻatagaina mea faʻaliliu e fusifusia i DNA ma toe faʻagaoioia genes suppressor tumo.

Fa'amatalaga saogalemu

Fa'ailoga oloa mata'utia: T

Fa'ailoga o vaega o lamatiaga: 45-46-22

Safety instructions: 53-22-36/37/39-45

WGK Siamani: 3

Numera RTECS: XZ3017500

F: 10-23

Fa'ailoga Tiute: 29349990

Oona Faʻamatalaga: 320-67-2

Oona: LD50 i isumu (mg/kg): 115.9 ip; 572.3 Tutala (Palm, Kensler)

Gaioiga faʻataʻitaʻi

Azacytidine fa'aaogaina lona aafiaga anti-tumo e ala i le fa'aitiitia o le DNA methylation ma le fa'ao'oina sa'o o le cytotoxicity i luga o ga'o ponaivi e le masani ai sela hematopoietic. O suʻesuʻega in vitro ua faʻaalia ai o le faʻaogaina o lenei oloa i le maualuga o le faʻasaina o le DNA methylation e le faʻalavelave tele ai le DNA synthesis. O le tulaga o le maualalo o le methylation e mafai ona toe faʻafoʻisia le galuega masani o kenera e vavalalata vavalalata ma le faʻavasegaina ma le faʻateleina o tusi vailaʻau lelei. O le a'afiaga o le cytotoxic o lenei oloa e mafai ona mafua ai le oti o sela o lo'o televave fa'ateleina, e aofia ai sela o le kanesa ua leiloa le fa'atonutonuina o masini masani, a'o sela e le fa'atuputeleina e fai lava si le mautonu i lenei oloa. Vaʻaiga lautele, mea faʻapitoa faʻapitoa, metotia sauniuni, aʻafiaga faʻafomaʻi, ma faʻaogaina o le azacitidine

O lo tatou avanoa

Mauoa poto masani: matou 13 Tausaga o tomai faʻapitoa;

Tagata fa'atau i le lalolagi atoa: fa'atau atu i le silia ma le 100 atunuu;

Tuuina atu oloa eseese: o oloa ua faʻaaogaina i faʻailoga tetele faʻavaomalo uma i vaega o vailaʻau, meaʻai faaopoopo, mea teuteu, meaʻai manu ma meaʻai aoga.

Tau i luma: maualalo MOQ ma tau tauva;

Tulaga lelei: ISO; Halal; Kosher fa'amaonia

Au'aunaga ina ua mae'a fa'atau: Au'aunaga fa'apolofesa 7 * 24 itula tagata fa'atau.

I se aotelega, i le avea ai ma se tagata tomai faapitoa Azacitidine API gaosi oloa, o loʻo i ai a matou tekonolosi faʻapitoa, fua faʻatatau, le tulaga sili ona lelei, poto masani gaosiga mauoa, ma auaunaga sili ona lelei. O nei tulaga lelei o le a fa'aalia ai i le tauvaga maketi ma manumalo atili ai le fa'atuatuaina ma le lagolago a tagata fa'atau.

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