2-Deoxy-D-glucose powder Supplier

Xi'an Yihui Kamupani ose fa'apolofesa gaosi oloa sili 2-Deoxy-D-kulukose paʻu. E mafai ona matou gaosia le 2DG ma le 99.9% anotusi. E mafai ona faʻaaogaina i meaʻai, vailaʻau, mea tau soifua maloloina, poʻo mea teuteu ma faʻafetaui tulaga USP, BP, EP, CP. E mafai ona matou ofoina atu ia te oe oloa sili ona maualuga i tau sili ona tauva. O lau filifiliga sili mo se fa'atau oloa 2DG ta'uta'ua ole Xi'an Yihui Company!

O le a le 2-Deoxy-D-glucose pa'u?

2- Deoxy- D- glucose paʻu o se vailaʻau vailaʻau, o lona fua faʻatatau o le C6H12O5 ma lona mamafa mole e 164.16 g/ spook, lona CAS NO. o 154-17-6. O le suka ono-carbon e tutusa ma le kulukose, ae leai se vaega hydroxyl i le isi kaponi snippet, o lea ua taʻua ai le "deoxy" glucose. Ose pa'epa'e pa'epa'e ma maualalo soluble i le vai. O le 2DG o se faʻalavelave faʻalavelave faʻafuaseʻi e mafai ona faʻalavelaveina le faʻaogaina ma le faʻaogaina o le kulukose cell, e oʻo atu ai i le pa'ū i tulaga ATP i totonu o sela.

O lenei vailaʻau e masani ona galue i luga o sela tumo ma nisi o faʻamaʻi e faʻalagolago i le suka e avea ma o latou meaʻai faʻasolosolo. O le fa'aaogaina o le 2DG e mafai ona fa'aoso lelei ai nei sela e mate pe fa'agesegese ai lo latou tuputupu a'e. E le gata i lea, o le 2DG o loʻo faʻaaogaina e avea o se meafaigaluega i suʻesuʻega o le neuroscience ma le metabolism aua e mafai ona faʻataʻitaʻiina le tulaga o le vaivai o le metabolic, faʻaalia faʻamatalaga o auala feaveaʻi.

O le mauaina o le 2- Deoxy-D- glucose e mafai ona toe maua i tua i le amataga o le 1950s. I lena taimi, na maua ai e saienitisi Amerika o Haskell Smith ma Morris Ficher se emulsion e taʻua o le 2-deoxyglucose aʻo suʻesuʻeina le faʻaogaina o le kulukose sela. Mulimuli ane, na iloa ai e le isi saienitisi o Takashi Otsuka e mafai e le kulukose 2-deoxy ona ofi i le metabolism o le kulukose sela ma taofia ai le vaevaega o sela i le taimi o le tuufaatasia o DNA.

Mulimuli ane, na faia e saienitisi nisi suʻesuʻega i 2-DG pauta ma fa'atūina e mafai ona fa'alavelaveina le tupu a'e o nisi sela ma fa'ama'i a'o iai ni oloa laiti i sela masani.

Ina ia faʻaleleia le aoga o le 2DG, na amata ai e saienitisi ona mamanuina ma tuʻufaʻatasia motes tutusa. I lenei faagasologa, na latou faʻatūina ai o le 2DG o se faʻalavelave faʻalavelave faʻafuaseʻi sili atu ona lelei, e mafai ona sili atu le faʻaogaina o le faʻaogaina o le kulukose cell ma le faʻaogaina. I le taimi nei, ua avea le 2DG ma meafaigaluega faʻataʻitaʻi taua ma vailaʻau faʻapitoa.

Faamatalaga autu

Tulaga o le tulaga lelei

Fa'agasologa Fa'atasi

O le faagasologa o le tuufaatasia o 2-deoxy-D-kulukose pafur e aofia ai laasaga e lua:

I le laasaga muamua, o le kulukose o loʻo tuʻuina atu i le Knoevenagel condensation e ala i le tali atu i le methyl vinyl ketone e maua ai le α,β-unsaturated carbonyl compound.

I le la'asaga lona lua, tO le fa'aputuga e le tu'u ua fa'aitiitia i le oloa fa'atatau 2-deoxy-D-glucose e ala i le fa'aitiitiga o le hydrogenation.

O fa'agaioiga fa'atupu fa'apitoa nei:

Laasaga muamua fa'atusa tali:

Kulukose + Methyl vinyl ketone → α,β-unsaturated carbonyl compound

Laasaga muamua faiga tali:

I lalo o tulaga alkaline, o le kulukose ma le methyl vinyl ketone o loʻo galue e pei o nucleophilic reagents ma faia Knoevenagel condensation faʻatasi ai ma le fesoasoani a le thioacetone poʻo le sodium hydroxide, e maua ai le α, β-unsaturated carbonyl compound.

Laasaga lona lua fa'atusa tali:

α,β-le fa'a'unsaturated carbonyl compound + Hydrogen gas + Catalyst → 2-deoxy-D-glucose

Laasaga lona lua faiga tali:

I le i ai o le kasa hydrogen ma se fa'amalosi, o le- emulsion carbonyl e le'o tumu e fa'asuavaia e maua mai ai le 2- deoxy- D- kulukose. O se essence catalyst e tutusa ma le platinum po'o le puipuiga e masani ona fa'aogaina mo lenei tali hydrogenation.

E tatau ona maitauina e na'o le tasi le sitaili masani mo le tu'ufa'atasia o le 2- deoxy- D- glucose. O le mea moni, o loʻo i ai isi auala faʻapipiʻi eseese, e tutusa ma le toe iloiloga o vailaʻau o le uracil ma microbial metabolism.

ose mea taua tele e masani ona faʻaaogaina i vailaʻau, biotechnology, ma le alamanuia meaʻai. O nisi nei o mea lelei:

E leai ni a'afiaga o'ona i le tino o le tagata ma e iai sona aafiaga fa'atosina i sela o le kanesa;

E iai le anti-virus, antifungal, anti-diabetes, anti-obesity ma isi aafiaga;

E mafai ona mitiia ma metabolized e le tino o le tagata;

E mafai ona fa'aaogaina e fai ma mea fa'aigoa fa'asalalau po'o se sui toe faaleleia DNA i le biotechnology;

E mafai ona faʻaaogaina e avea o se meaʻai suamalie maualalo-kalori i totonu o pisinisi taumafa;

I se faapuupuuga, o se tuufaatasiga sili ona aoga ma faʻaoga eseese.

O le a le aoga o le 2 Deoxy Glucose?

2 deoxy glucose(2DG) o se kulukose fa'atusa e leai se vaega o le hydroxyl i le tulaga 2 o le mama kulukose. E masani ona fa'aoga i su'esu'ega fa'asaienisi e fai ma mea faigaluega e su'esu'e ai le metabolism o le kulukose ma ona ala feso'ota'i. O nisi nei o ana galuega tauave:

1. O aseta o le glycolysis 2DG e ave i luga e sela e ala i le kulukose transporters ma phosphorylated e hexokinase i le 2DG-6-phosphate, lea e le mafai ona sili atu metabolized e glycolysis. o le mea lea, e mafai e le 2DG ona faʻatauvaʻa le faʻaogaina o le kulukose ma le glycolysis, o le laasaga muamua lea i le metabolism malosi.

2. Debaser o le autophagy Autophagy o se fa'aogaina fa'aitiitiga fa'aautu e fesoasoani e fa'amautu le homeostasis feavea'i e ala i le toe fa'aleleia o polotini ma okeni ua fa'aleagaina pe le mana'omia. O le 2DG e faʻaosofia ai le autophagy e ala i le faʻalavelaveina o le taulaʻi mama o le rapamycin (mTOR) ala, e taʻitaʻia ai le faʻagaoioia o kenera e fesoʻotaʻi ma autophagy.

3. Radiosensitizer: O sela o le kanesa e maualuga atu le kulukose ma le glycolytic flux nai lo sela masani, lea e lauiloa o le Warburg effect. O le mea lea, e mafai e le 2DG ona fa'amanino le fa'amanino o sela o le kanesa i le leitio e ala i le taofiofia o le glycolysis ma le fa'aleleia atili o tali fa'alavelave.

4. toe fa'aleleia mo tulaga o le neurodegenerative 2DG ua fa'aalia e fa'aleleia ai le mafaufau ma fa'aitiitia le neuropathology i manu fa'ata'ita'iga o le fa'asea a Alzheimer ma le fa'asea a Parkinson. E ono a'afia ai le fa'aleleia o le kulukose metabolism i le fai'ai, fa'aitiitia ai le mumu o le neuronal ma le fa'ama'i fa'ama'i.

5. Meafaigaluega mo le fa'ailogaina o le metabolic Ona o lona fa'apena-pei o le kulukose ma mafai ona tu'u fa'atasi i le glycolysis, 2-deoxy-d-glucose API e mafai ona faʻaaogaina e fai ma faʻailoga metabolic e suʻesuʻe ai le faʻalavelave faʻafuaseʻi o kulukose-toʻesea motes i sela ma apkins.

I se aotelega,2-deoxy d kulukose e tele galuega taua i suʻesuʻega faʻasaienisi, e aofia ai le avea ma se inhibitor o le glycolysis, o se faʻaosoina o le autophagy, o se radiosensitizer, o se togafitiga faʻamaʻi mo faʻamaʻi neurodegenerative, ma se meafaigaluega mo le faʻailogaina o le metabolic. O ana fa'aoga e iai a'afiaga fa'apitoa mo su'esu'ega fa'asaienisi ma vaila'au fa'afoma'i.

Teuina & Vaa

Teuina ：1kg/pepa pepa; 5kg/carton; 25kg/fibre drum; poʻo le faʻapipiʻiina o lau talosaga.

Faʻasalalauga:

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Faʻapipiʻi faʻatau

Faʻafanua masani

Taimi ta'ita'i: I totonu ole 3 aso faigaluega ina ua uma ona maua le totogi.

o Vaa

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Aisea e Filifilia ai Xi'an Yihui?

Tali a tagata

Xi'an Yihui tusipasi

O lo tatou lelei

Mauoa poto masani: matou 13 Tausaga o tomai faʻapitoa;

Tagata fa'atau i le lalolagi atoa: fa'atau atu i le silia ma le 100 atunuu;

Tuuina atu oloa eseese: o oloa ua faʻaaogaina i faʻailoga tetele faʻavaomalo uma i vaega o vailaʻau, meaʻai faaopoopo, mea teuteu, meaʻai manu, ma meaʻai aoga.

Tau i luma: maualalo MOQ ma tau tauva;

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Au'aunaga ina ua mae'a fa'atau: Au'aunaga fa'apolofesa 7 * 24 itula tagata fa'atau.

i le faaiuga

I se aotelega, i le avea ai ma se tagata tomai faapitoa 2-Deoxy-D-kulukose paʻu gaosi oloa, o loʻo i ai a matou tekonolosi faʻapitoa, fua faʻatatau, le tulaga sili ona lelei, poto masani gaosiga mauoa, ma auaunaga sili ona lelei. O nei tulaga lelei o le a fa'aalia ai i le tauvaga maketi ma manumalo atili ai le fa'atuatuaina ma le lagolago a tagata fa'atau.

Afai e te fia iloa atili e uiga i 2-DG pe e fiafia e faʻatau, e mafai ona e faʻafesoʻotaʻi matou i soʻo se taimi. Matou te tali atu ia te oe i se taimi vave pe a uma ona matou vaʻai i le feʻau.

matou fa'amatalaga fa'afeso'ota'i:

E-mail: sales@yihuipharm.com
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